Kidney Disease

Kidney injury molecule linked to chronic kidney disease

October 2, 2013

More than 15 years after the discovery of kidney injury molecule-1 (KIM-1) by Joseph Bonventre, MD, PhD, researchers in the HSCI Kidney Disease Program—of which Bonventre is a member—have found that the molecule promotes the scar tissue formation typically associated with chronic kidney disease, which affects approximately 9-10 percent of the world’s population. The finding was made in mice.

Patient stem cells offer insight into origins of polycystic kidney disease

September 28, 2013

Harvard Stem Cell Institute (HSCI) scientists have identified a new therapeutic approach for treating polycystic kidney disease (PKD), one of the most common life threatening, inherited diseases in humans, affecting more than 1 in 500 individuals. Patients with the disease experience an abnormal proliferation of kidney cells that ultimately results in cysts and a decline in organ function leading to kidney failure.