Dr. Bonventre is Chief of the Renal Unit and Director of the Bioengineering Division at Brigham and Women’s Hospital and has had a long-standing interest in various aspects of cellular injury and repair mechanisms in the kidney with a special emphasis on the role of inflammation, biomarkers and stem cells.
Massachusetts General Hospital
Harvard Medical School
We study kidney organogenesis using the zebrafish to explore conserved molecular mechanisms underlying kidney cell specification, differentiation, and organ patterning. We also study organ pathologies that results from mutations in genes required for cilia biogenesis and function. These include kidney cystic disease, retinal degeneration and left-right asymmetry defects.
The mission of the Humphreys Lab is to understand the cellular and molecular mechanisms of kidney injury and repair and to translate this knowledge into new therapeutic strategies to treat patients suffering from kidney disease.