With a series of rodent models Dr. Bonner-Weir has provided compelling evidence that adult pancreatic beta-cell mass increases in response to a metabolic need and have been examining the mechanisms of this postnatal pancreatic growth.
Brigham and Women's Hospital
Harvard University Department of Stem Cell and Regenerative Biology
Harvard Medical School
The Lee Laboratory uses biotechnologies to discover and design new approaches to cardiovascular and metabolic diseases. We work at this interface using a broad variety of techniques in genomics, stem cell biology, and molecular biology. Our approach is to understand human problems and design solutions in the laboratory, and then we demonstrate the effectiveness of these solutions in vivo. Ongoing projects in the laboratory include studies of cardiac regeneration, diabetes, aging and metabolism.
One of the most important goals of diabetes research is to find sources of new beta cells (the islet cells in the pancreas that produce insulin) and to successfully transplant these cells into the pancreas.