Brigham and Women's Hospital

Benjamin Ebert, MD

Benjamin Ebert, MD

Brigham and Women's Hospital
Harvard Medical School

We study the biology and treatment of cancer using hematopoiesis as a model system. The laboratory employs a range of genomic technologies as well as classical cellular and molecular biology approaches to investigate the biology of specific human diseases, particularly hematopoietic malignancies and disorders of red blood cell production.

Yick W. Fong, PhD

Yick W. Fong, PhD

Brigham and Women's Hospital
Harvard Medical School

Transcriptional mechanisms of pluripotency and cellular reprogramming

We study key transcriptional and gene regulatory events that lead to the acquisition and maintenance of pluripotency in embryonic stem cells (ESCs).  ESCs can self-renew or differentiate to produce most of the cells of the body. These distinct but developmentally relevant cell fates are defined by their unique gene expression signatures. Proper execution of these developmental programs requires the precise tuning of gene expression by transcription factors, coactivators and corepressors.  Indeed, aberrant transcriptional regulation is the root of many human diseases including developmental disorders, cancers and degenerative diseases. 

Wolfram Goessling, MD, PhD

Wolfram Goessling, MD, PhD

Brigham and Women's Hospital
Dana-Farber Cancer Institute
Harvard Medical School

Developmental signaling pathways govern the formation and function of stem cells, thereby holding the key to unlocking the promise of adult tissue regeneration, and to inhibiting cancer development. In our laboratory, we use zebrafish as the primary model to study the liver and explore the regulation of endodermal progenitor cell specification, organ differentiation and growth.

Jeffrey Karp, PhD

Jeffrey Karp, PhD

Brigham & Women's Hospital
Harvard Medical School
Harvard-MIT Division of Health Sciences and Technology

Dr. Jeff Karp is an Associate Professor at Brigham and Women’s Hospital, Harvard Medical School, and is Principal Faculty at the Harvard Stem Cell Institute, an affiliate faculty at MIT through the Harvard-MIT Division of Health Sciences and Technology, and an affiliate faculty at the Broad Institute.

Thomas S. Kupper, MD

Thomas S. Kupper, MD

Brigham and Women's Hospital
Dana-Farber Cancer Institute
Harvard Medical School

Our laboratory is interested in how immune responses in skin are initiated, and how T cell mediated memory responses occur in skin, and in particular a newly described population of antigen experienced T cells known as Resident Memory T Cell (TRM).

Richard Lee, MD

Richard Lee, MD

Brigham and Women's Hospital
Harvard Department of Stem Cell and Regenerative Biology
Harvard Medical School

The Lee Laboratory uses biotechnologies to discover and design new approaches to cardiovascular and metabolic diseases. We work at this interface using a broad variety of techniques in genomics, stem cell biology, and molecular biology.

Kiran Musunuru, MD, PhD, MPH

Kiran Musunuru, MD, PhD, MPH

Harvard Department of Stem Cell and Regenerative Biology
Brigham and Women's Hospital
The Broad Institute

Our goal is to understand how naturally occurring human genetic variation protects (or predisposes) some people to cardiovascular and metabolic disease—the leading cause of death in the world—and to use that information to develop therapies that can protect the entire population from disease.

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